Neuroimaging analysis demonstrates that normative brain hub disruption predicts long-term seizure recurrence in temporal lobe epilepsy, highlighting connectome integrity as a surgical outcome...
Patients with temporal lobe epilepsy (TLE) can achieve seizure freedom in the early period after surgery, yet up to half experience seizure recurrence in the following years (i.e., long-term). TLE is associated with disruption of highly connected brain regions (hubs), which may reduce the likelihood of long-term surgical success. We tested whether disruption of physiologic (normative) hubs predicts long-term seizure outcomes.
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Karpychev et al. (2026) studied this question.
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