Key result
Dual-mode RFA catheter causes up to ~90% collagen denaturation in smooth muscle bundles in vitro.
Why the study?
Existing imported radiofrequency ablation devices carry a high risk of thermal injury and are incompatible with the 6 Fr sheaths commonly used in domestic clinical practice.
Does the Saphenus radiofrequency ablation catheter system achieve effective vascular closure and reduce thermal injury compared to existing devices in a preclinical goat model?
Does the Saphenus radiofrequency ablation catheter system achieve effective vascular closure and reduce thermal injury compared to existing devices in a preclinical goat model?
The novel Saphenus RFA catheter provides effective vein occlusion with reduced thermal injury risk in a preclinical goat model, offering a promising domestic alternative for treating lower extremity venous insufficiency.
Answers are grounded in this paper and cite their sources.
Animal data should not alter current vein ablation practice; leaves open first-in-human testing of this lower-injury RFA system.
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Gu et al. (2026) studied Saphenous and perforator vein insufficiency. Dual-mode radiofrequency ablation catheter vs. 120 ℃ (Control) was evaluated on Collagen denaturation/degeneration in smooth muscle bundles. In vitro testing of a dual-mode radiofrequency ablation catheter demonstrated that temperatures between 60 and 90 ℃ caused 30% to 90% collagen denaturation in smooth muscle bundles.
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