What is the clinical evidence from this study?

Study design: Case Report. Population: Neuroinvasive West Nile virus infection (n=1). Intervention: West Nile virus infection. Primary outcome: Neurologic manifestations (acute flaccid paralysis evolving to Guillain-Barré syndrome).

What question did this study set out to answer?

To describe an atypical case of neuroinvasive West Nile virus infection presenting sequentially with acute flaccid paralysis and Guillain-Barré syndrome.

August 15, 2026CureusOpen Access

Acute Flaccid Paralysis Followed by Guillain-Barré Syndrome in West Nile Virus Infection: A Case Report

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Key result

Neuroinvasive West Nile virus infection presents as acute flaccid paralysis evolving into Guillain-Barré syndrome.

Why the study?

Neuroinvasive West Nile virus infection presents with a broad spectrum of neurologic manifestations, creating diagnostic and management challenges.

Design

Case report

Authors

YKYae Eun Kim MSMichael SuhUniversity of the Pacific

Discussion

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Implication

Ongoing reassessment is prudent but should not yet change practice; leaves open the incidence of AFP-to-GBS overlap in WNV.

Key Points

To describe an atypical case of neuroinvasive West Nile virus infection presenting sequentially with acute flaccid paralysis and Guillain-Barré syndrome.
Clinical evaluation and longitudinal inpatient monitoring of a single patient diagnosed with neuroinvasive West Nile virus infection.
Serial neurologic assessments tracking evolving neuromuscular and peripheral nerve involvement during hospitalization.
The patient initially presented with acute flaccid paralysis following neuroinvasive West Nile virus infection.
Clinical presentation progressively evolved during hospitalization to encompass features consistent with Guillain-Barré syndrome.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

1 patient with neuroinvasive West Nile virus infection presenting with acute flaccid paralysis evolving into Guillain-Barré syndrome.

Neuroinvasive West Nile virus infection can present with acute flaccid paralysis that evolves into Guillain-Barré syndrome, requiring ongoing clinical reassessment.

Cite This Study

Kim et al. (2026) conducted a case report in Neuroinvasive West Nile virus infection (n=1). West Nile virus infection was evaluated on Neurologic manifestations (acute flaccid paralysis evolving to Guillain-Barré syndrome). A patient with neuroinvasive West Nile virus infection initially presented with acute flaccid paralysis that subsequently evolved into Guillain-Barré syndrome during hospitalization.

synapsesocial.com/papers/6a80197375c2e31742c857ac https://doi.org/10.7759/cureus.114438

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Acute Flaccid Paralysis Followed by Guillain-Barré Syndrome in West Nile Virus Infection: A Case Report

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Acute Flaccid Paralysis Followed by Guillain-Barré Syndrome in West Nile Virus Infection: A Case Report

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider