What question did this study set out to answer?

To synthesize the molecular landscape of salivary gland carcinomas and evaluate current and emerging precision oncology approaches across diverse histological subtypes.

August 15, 2026ESMO rare cancers.Open Access

Precision oncology in salivary gland cancer: molecular landscape, therapeutic advances and emerging strategies

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To synthesize the molecular landscape of salivary gland carcinomas and evaluate current and emerging precision oncology approaches across diverse histological subtypes.
Reviewed molecular profiling data and clinical trial findings across 21 histological subtypes of salivary gland carcinomas.
Assessed targeted therapies (TRK inhibitors, HER2-directed agents, androgen receptor blockers), immunotherapy, and emerging treatment platforms including antibody-drug conjugates.
Comprehensive genomic profiling identified clinically actionable targets including NTRK fusions, HER2 amplification, and androgen receptor overexpression, which respond favorably to matched targeted agents.
Traditional chemotherapy and immune checkpoint monotherapies show modest efficacy, highlighting the need for combinatorial regimens and novel platforms such as bispecific antibodies, radioligand therapy, and cellular therapies.

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Implication

Narrative review reveals actionable genomic alterations and novel targeted therapies in salivary gland carcinomas, suggesting precision oncology improves recurrent and metastatic disease outcomes.

Cite This Study

Cheo et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c857b0 https://doi.org/10.1016/j.esmorc.2026.100524

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Implication

Narrative review reveals actionable genomic alterations and novel targeted therapies in salivary gland carcinomas, suggesting precision oncology improves recurrent and metastatic disease outcomes.

Precision oncology in salivary gland cancer: molecular landscape, therapeutic advances and emerging strategies

Key Points

Discussion

Implication

Cite This Study

Precision oncology in salivary gland cancer: molecular landscape, therapeutic advances and emerging strategies

Key Points

Discussion

Implication

Cite This Study

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