What question did this study set out to answer?

Validate the Persian Rome IV diagnostic questionnaire and develop population-adapted diagnostic criteria for functional dyspepsia, irritable bowel syndrome, and functional constipation.

August 15, 2026BMC GastroenterologyOpen Access

Accuracy of Rome IV questionnaire: a population-based study on diagnostic definitions and clinical validity

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Authors

MDMehdi DehghaniIsfahan University of Medical Sciences AFAwat FeiziIsfahan University of Medical Sciences HRHamidreza RoohafzaCross-Cutting Cardiology

Discussion

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Implication

Population-based study demonstrates tailored diagnostic thresholds improve detection of gut-brain disorders in an Iranian cohort, indicating standard Western criteria may misestimate prevalence.

Key Points

Validate the Persian Rome IV diagnostic questionnaire and develop population-adapted diagnostic criteria for functional dyspepsia, irritable bowel syndrome, and functional constipation.
Utilized the Isfahan functional disorders (ISFUN) dataset to assess standard Rome IV Diagnostic Criteria (R4DC) and two modified models: Modified Iranian Criteria (mIrC) based on 90th percentile symptom frequencies and Clinically-Adjusted Criteria (CAC) derived via ROC analysis.
Evaluated diagnostic accuracy, clinical agreement with reference standards, and convergent validity using the Somatic Symptom Disorder-B Criteria Scale (SSD-12).
Standard R4DC overestimated functional constipation prevalence (23.4% vs. 13.9%) and underestimated functional dyspepsia and irritable bowel syndrome due to low sensitivity despite high specificity.
mIrC increased specificity (functional dyspepsia: 95.6%, functional constipation: 93.0%) but lowered sensitivity, whereas CAC maximized sensitivity (functional dyspepsia: 75.0%, irritable bowel syndrome: 84.2%, functional constipation: 96.8%).
SSD-12 scores were significantly higher across all diagnostic groups (p < 0.001), confirming robust convergent validity.

Cite This Study

Dehghani et al. (2026) studied this question.

synapsesocial.com/papers/6a8019bb75c2e31742c85e00 https://doi.org/10.1186/s12876-026-05189-3

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Implication

Population-based study demonstrates tailored diagnostic thresholds improve detection of gut-brain disorders in an Iranian cohort, indicating standard Western criteria may misestimate prevalence.

Accuracy of Rome IV questionnaire: a population-based study on diagnostic definitions and clinical validity

Discussion

Member takes

Implication

Key Points

Cite This Study

Accuracy of Rome IV questionnaire: a population-based study on diagnostic definitions and clinical validity

Discussion

Member takes

Implication

Key Points

Cite This Study

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