Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 15, 2026MedicinaOpen Access

The Obesity–Bone Paradox in Postmenopausal Women: Divergent Associations of BMI with Bone Mineral Density and Trabecular Bone Score in a Real-World DXA Cohort

View Full Paper
Ask AI
Bookmark
Share

Authors

RBRobert BotUniversity of OradeaSCSimona CavaluUniversity of Oradea

Discussion

Loading...

Member takes

Implication

Retrospective observational study reveals higher BMI correlates with increased bone mineral density but degraded trabecular bone score in postmenopausal women, indicating masked microarchitectural...

Key Points

  • To evaluate the relationship between body mass index, bone mineral density, and trabecular bone score in postmenopausal women, assessing the frequency of discordant skeletal phenotypes.
  • Retrospective observational study of 106 postmenopausal women (mean age 65.2 ± 7.6 years, mean BMI 27.3 ± 4.5 kg/m²) evaluated at a tertiary DXA center.
  • Extracted lumbar spine and hip bone mineral density (BMD), T-scores, and lumbar trabecular bone scores (TBS) across weight categories (under/normal-weight, overweight, obesity).
  • Assessed independent relationships using correlation analyses, group comparisons, and multivariable linear regression models adjusting for age, years since menopause, and BMD.
  • BMI was positively associated with lumbar spine BMD (r = 0.392, p < 0.001), minimum femoral neck BMD (r = 0.382, p < 0.001), and minimum total hip BMD (r = 0.508, p < 0.001), but negatively associated with TBS (r = −0.307, p = 0.001).
  • Mean TBS decreased across weight categories: 1.283 ± 0.084 in under/normal-weight, 1.255 ± 0.088 in overweight, and 1.199 ± 0.109 in obesity groups.
  • In fully adjusted multivariable regression, BMI remained an independent negative predictor of TBS (β = −0.0126, p < 0.001), with discordant non-osteoporotic BMD and degraded TBS occurring more frequently in obesity.

Cite This Study

Bot et al. (2026) studied this question.

synapsesocial.com/papers/6a8019f175c2e31742c863bbhttps://doi.org/10.3390/medicina62081555
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of body mass index and bone mineral density in postmenopausal women: a systematic review and meta-analysis2025 · 9 citations
  2. 2Sex and Obesity-Specific Associations of Ultrasound-Assessed Radial Velocity of Sound with Body Composition2024 · 1 citations
  3. 3Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox2021 · 14 citations
  4. 4Body Mass Index May Positively Correlate with Bone Mineral Density of Lumbar Vertebra and Femoral Neck in Postmenopausal Females2016 · 59 citations
  5. 5High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes Mellitus2010 · 460 citations