What question did this study set out to answer?

To examine the relationships between fatigue, balance impairment, and task-evoked cortical hemodynamics and functional connectivity during a postural control task in people with multiple sclerosis.

August 15, 2026SensorsOpen Access

Brain Activity and Connectivity in Fatigued People with Multiple Sclerosis During a Static Balance Task: An fNIRS Study

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To examine the relationships between fatigue, balance impairment, and task-evoked cortical hemodynamics and functional connectivity during a postural control task in people with multiple sclerosis.
Enrolled 16 participants with relapsing-remitting multiple sclerosis (EDSS < 3.5; 10 fatigued with MFIS ≥ 38, 6 non-fatigued) and 19 healthy controls.
Participants performed five 30-second trials of static stance on foam with eyes closed while fNIRS measured frontal, temporal, and occipital hemodynamics and stabilometry assessed center-of-pressure sway.
Fatigued participants with multiple sclerosis exhibited greater hemodynamic responses in bilateral Brodmann area 10 (BA10) and temporo-parietal regions compared with non-fatigued participants and healthy controls.
Exploratory analysis showed significantly higher BA10 prefrontal functional coherence in fatigued versus non-fatigued individuals (p = 0.02), alongside a non-significant trend between fatigue score and postural sway (r = 0.49; p = 0.06; sway ANOVA p = 0.341).

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Implication

Cross-sectional study reveals increased prefrontal activation and hyper-connectivity during standing balance in fatigued multiple sclerosis patients, suggesting compensatory top-down control.

Cite This Study

Cattaneo et al. (2026) studied this question.

synapsesocial.com/papers/6a801a0e75c2e31742c866ff https://doi.org/10.3390/s26165131

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Implication

Cross-sectional study reveals increased prefrontal activation and hyper-connectivity during standing balance in fatigued multiple sclerosis patients, suggesting compensatory top-down control.

Brain Activity and Connectivity in Fatigued People with Multiple Sclerosis During a Static Balance Task: An fNIRS Study

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Discussion

Implication

Cite This Study

Brain Activity and Connectivity in Fatigued People with Multiple Sclerosis During a Static Balance Task: An fNIRS Study

Key Points

Discussion

Implication

Cite This Study

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