Low muscle quality, but not muscle mass, in abdominal CT-scans associates with adverse outcomes in AML patients undergoing an allogeneic stem cell transplantation

Jule Ussmann; Clara Wall; Lara Bischof; Jacob Jendro; Sofia Voigt; Dominic Brauer; Donata Backhaus; Maximilian Merz; Vladan Vučinić; Marco Herling; Carmen Herling; Georg‐Nikolaus Franke; Uwe Platzbecker; Timm Denecke; Klaus H. Metzeler; Sebastian Schwind; Hans‐Jonas Meyer; Madlen Jentzsch

doi:10.1038/s41409-026-03005-w

Key Points

To evaluate the association between abdominal CT-derived muscle quality and muscle mass with clinical outcomes in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation.
Assessed muscle mass and muscle quality using abdominal computed tomography (CT) scans in acute myeloid leukemia (AML) patients.
Evaluated clinical post-transplant outcomes, focusing on risk factors related to non-relapse mortality following allogeneic hematopoietic stem cell transplantation (HSCT).
Low muscle quality, but not total muscle mass, significantly associated with adverse clinical outcomes in AML patients undergoing allogeneic HSCT.
Non-relapse mortality remains a major post-transplant risk, with cumulative incidence reaching up to 49% at 3 years.

Implication

Observational study reveals low muscle quality on CT scans associates with adverse outcomes in AML transplant recipients, indicating a potential target to reduce non-relapse mortality.

Abstract

For many patients with acute myeloid leukemia (AML), allogeneic hematopoietic stem cell transplantation (HSCT) remains the treatment with the highest curative potential. Non-relapse mortality (NRM) is a relevant competing risk after HSCT, with a cumulative risk affecting up to 49% of patients after 3 years [ 1 ]. Patient-specific and—to some extent—modifiable factors to potentially reduce NRM are lacking.

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Cite This Study

Ussmann et al. (2026) studied this question.

synapsesocial.com/papers/6a801a2875c2e31742c86a93 https://doi.org/10.1038/s41409-026-03005-w

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Low muscle quality, but not muscle mass, in abdominal CT-scans associates with adverse outcomes in AML patients undergoing an allogeneic stem cell transplantation

Key Points

Implication

Abstract

Discussion

Cite This Study

Low muscle quality, but not muscle mass, in abdominal CT-scans associates with adverse outcomes in AML patients undergoing an allogeneic stem cell transplantation

Key Points

Implication

Abstract

Discussion

Cite This Study

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