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December 8, 2025BloodOpen Access

Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.

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Authors

MLMyriam LabopinIYIbrahim Yakoub‐AghaMSMatthias Stelljes

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Overview

Analysis from EBMT shows haploidentical transplants improve graft-versus-host disease and overall survival in AML patients with detectable MRD.

Key Points

  • This study aims to compare outcomes of haploidentical vs matched sibling donor transplants in AML patients with detectable MRD.
  • Analyzed data from 3385 adult AML patients undergoing first allo-HCT in CR with detectable MRD.
  • Used multivariable Cox regression models to assess impact of donor types on outcomes.
  • Excluded transplants from HLA-mismatched unrelated donors or those with ex-vivo manipulation.
  • Haploidentical transplants showed better LFS and GRFS compared to matched sibling donor transplants.
  • MSD transplants associated with higher disease relapse risk and lower non-relapse mortality.
  • Older patients had higher non-relapse mortality and poorer overall survival.

Cite This Study

Labopin et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d758https://doi.org/10.1182/blood-2025-1059
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  2. 2Non‐T‐Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation From Matched Siblings or Unrelated Donors in Patients With Secondary <scp>AML</scp> in First Complete Remission: A Study From the <scp>ALWP</scp> / <scp>EBMT</scp>2025 · 5 citations
  3. 3T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  4. 4Lower relapse incidence with haploidentical versus matched sibling or unrelated donor hematopoietic cell transplantation for core‐binding factor <scp>AML</scp> patients in <scp>CR2</scp>: A study from the Global Committee and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation2024 · 12 citations
  5. 5Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT2025