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December 8, 2025BloodOpen Access

Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation

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Authors

DWDepei WuIBIgor Wolfgang BlauJBJenny Byrne

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Overview

Retrospective analysis shows that matched sibling donors improve survival in older AML patients, highlighting graft-versus-host disease effects.

Key Points

  • This study examines the impact of different donor types on survival outcomes in older patients with AML undergoing allo-HCT.
  • Retrospective data analysis from the EBMT registry.
  • Older patients aged 68 and above with AML in second complete remission analyzed.
  • Patients grouped by donor type: matched sibling, haploidentical, and unrelated.
  • Matched sibling donor group had the highest overall survival at 65.7%, compared to haploidentical at 53.7%.
  • Grade II-IV acute GVHD incidence was highest inhaploidentical recipients at 27.1%.
  • Older donor age correlated with increased non-relapse mortality and worse overall survival.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d487https://doi.org/10.1182/blood-2025-2528
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