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December 8, 2025BloodOpen Access

Young (35 years) matched sibling donors for allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT

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Authors

ANArnon NaglerAFAllain-Thibeault FerhatYKYener Koç

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Overview

Retrospective analysis shows no differences in graft-versus-host disease and survival in patients with sAML receiving transplants from young or older donors.

Key Points

  • To evaluate the outcomes of young haploidentical vs. older matched sibling donors in sAML patients post-HSCT with PTCy.
  • Conducted a registry-based retrospective analysis
  • Compared outcomes between 306 patients with young haploidentical donors and 100 with older matched sibling donors
  • Utilized statistical tests including multivariable analysis for data assessment.
  • No significant difference in transplant outcomes between donor groups
  • Higher incidence of non-relapse mortality and slower neutrophil engraftment in young haploidentical donor group
  • Lower incidence of extensive chronic graft-versus-host disease observed in young haploidentical donor group.

Cite This Study

Nagler et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d87fhttps://doi.org/10.1182/blood-2025-4193
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  2. 2Non‐T‐Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation From Matched Siblings or Unrelated Donors in Patients With Secondary <scp>AML</scp> in First Complete Remission: A Study From the <scp>ALWP</scp> / <scp>EBMT</scp>2025 · 5 citations
  3. 3Peripheral blood stem cells versus bone marrow graft for non-T-depleted haploidentical transplantation with post-transplant cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2026 · 1 citations
  4. 4Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  5. 5Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations