What question did this study set out to answer?

To compare outcomes of haploidentical transplantation and mismatched unrelated transplantation in patients with secondary acute myeloid leukemia.

December 8, 2025BloodOpen Access

T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT

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Authors

YKYener KoçIstanbul Eye Hospital JPJiří PavlůCharles University SSSimona SicaUniversità Cattolica del Sacro Cuore

Discussion

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Implication

Retrospective analysis finds no significant outcome differences between haploidentical and mismatched transplants in acute myeloid leukemia patients, suggesting alternatives are viable.

Key Points

To compare outcomes of haploidentical transplantation and mismatched unrelated transplantation in patients with secondary acute myeloid leukemia.
Retrospective comparison of haploidentical HSCT and mismatched unrelated HSCT
Population included patients with secondary acute myeloid leukemia in first complete remission
Utilized multivariate Cox regression model to assess outcomes
Haploidentical transplants were more recent; median year 2019
No significant differences in overall survival or leukemia-free survival between both transplant types
Faster neutrophil recovery observed in the mismatched group

Cite This Study

Koç et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cffc https://doi.org/10.1182/blood-2025-114

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Implication

Retrospective analysis finds no significant outcome differences between haploidentical and mismatched transplants in acute myeloid leukemia patients, suggesting alternatives are viable.

T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT

Discussion

Member takes

Implication

Key Points

Cite This Study

T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT

Discussion

Member takes

Implication

Key Points

Cite This Study

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