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December 6, 2025American Journal of HematologyOpen Access

Non‐T‐Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation From Matched Siblings or Unrelated Donors in Patients With Secondary AML in First Complete Remission: A Study From the ALWP / EBMT

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Authors

ANArnon NaglerSLSarah LindnerAFAllain Thibeault Ferhat

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Overview

Analysis reveals that haploidentical transplantation may reduce relapse risk in secondary AML patients, suggesting it as a viable treatment option.

Key Points

  • Hematopoietic stem cell transplantation reduced relapse risk for secondary AML patients in first complete remission.
  • Multivariate analysis showed a significant impact of donor type on relapse risk and overall survival.
  • Analysis of 3862 patients across multiple centers provided insights into transplant outcomes and risks, emphasizing donor choice.
  • Findings highlight the importance of considering donor types in treating secondary AML, with haploidentical transplantation being a solid alternative.

Cite This Study

Nagler et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb653https://doi.org/10.1002/ajh.70164
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