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December 8, 2025BloodOpen Access

Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT

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Authors

MNMaud NgoyaAKAlexander KulaginGHGrzegorz Helbig

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Overview

Retrospective analysis shows comparable overall survival and cancer control in T-ALL patients undergoing transplant from various donor types, indicating viable alternatives for treatment.

Key Points

  • This research aims to compare outcomes of different donor types in adult patients with T-cell acute lymphoblastic leukemia who received hematopoietic cell transplantation.
  • Retrospective analysis of data from EBMT for adult T-ALL patients in second complete remission.
  • Participants underwent their first allogeneic hematopoietic cell transplantation from matched sibling, haploidentical, or unrelated donors between 2010 and 2022.
  • Outcomes measured included overall survival, progression-free survival, and incidence of graft-versus-host disease.
  • No significant differences in 2-year overall survival across donor types (Haplo 46.4%, MSD 42.5%, UD 43.3%).
  • Progression-free survival was comparable among groups (Haplo 35.9%, MSD 37.1%, UD 35.6%).
  • Cytomegalovirus seropositivity was higher in matched sibling donor recipients compared to haploidentical and unrelated donor recipients.

Cite This Study

Ngoya et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d47fhttps://doi.org/10.1182/blood-2025-2526
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  2. 2Matched sibling donors still provide superior survival outcomes in older patients with AML in second complete remission. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation2025
  3. 3Donor-source-specific competing risks of relapse and non-relapse mortality in adult B-ALL allogeneic hematopoietic stem cell transplantation on a rabbit antithymocyte globulin-based platform2026
  4. 4Non‐T‐Depleted Haploidentical Transplantation Compared to Allogeneic Transplantation From Matched Siblings or Unrelated Donors in Patients With Secondary <scp>AML</scp> in First Complete Remission: A Study From the <scp>ALWP</scp> / <scp>EBMT</scp>2025 · 5 citations
  5. 5Mitigating HLA Disparity in AML Transplantation: Comparable Outcomes After Haploidentical and 9/10 Mismatched Unrelated Donor Transplantation With Treosulfan and PTCy2026