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December 8, 2025BloodOpen Access

Old mismatched donors are associated with inferior outcomes after allogeneic hematopoietic stem cell transplantation in myelodysplastic syndrome, but not in Acute Myeloid Leukemia

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Authors

YKYoungil KohHKHyo Jung Kim

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Overview

Retrospective analysis shows donor age affects outcomes in MDS, indicating old mismatched donors lead to worse survival.

Key Points

  • To evaluate the effect of donor age and type on outcomes of allogeneic hematopoietic stem cell transplantation in MDS and AML.
  • Retrospective analysis of adult AML and MDS patients who underwent alloHCT
  • Used busulfan/fludarabine conditioning and T-cell depletion
  • Classified donors by age and type
  • Compared survival and transplant-related outcomes
  • 320 patients included with outcomes analyzed by donor age and type
  • Old mismatched donors associated with significantly inferior overall survival in MDS
  • Multivariate analysis confirmed negative impact of age and donor type on outcomes

Cite This Study

Koh et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da2chttps://doi.org/10.1182/blood-2025-6052
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