This computational model demonstrates that progressive aortic valve calcification significantly reduces cardiac output and increases localized mechanical stress, particularly at leaflet connections.
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Does not support changes to AS intervention thresholds; leaves open this particle method for future CAVD hemodynamic studies.
This study proposes a 3D particle-based (discrete) multiphysics approach for modelling calcification in the aortic valve. Different stages of calcification (from mild to severe) were simulated, and their effects on the cardiac output were assessed. The cardiac flow rate decreases with the level of calcification. In particular, there is a critical level of calcification below which the flow rate decreases dramatically. Mechanical stress on the membrane is also calculated. The results show that, as calcification progresses, spots of high mechanical stress appear. Firstly, they concentrate in the regions connecting two leaflets; when severe calcification is reached, then they extend to the area at the basis of the valve.
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Mohammed et al. (2020) studied this question.
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