Key result
A computational model of the aortic valve successfully simulated the degradation of valve function over time, showing progressive narrowing of the valve orifice and increased peak fluid velocity in calcific aortic stenosis.
Population
Computational model of the aortic heart valve
Design
Other
Authors
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Hypothesis-generating model of aortic stenosis progression; leaves open validation before clinical or predictive use.
A novel computational model simulates the temporal progression of aortic valve calcification and aging to predict disease progression.
Weinberg et al. (2009) studied Calcific aortic stenosis. Simulated calcific aortic stenosis vs. Simulated normal aging was evaluated on Peak fluid velocity and aortic valve opening area (AVA). A computational model of the aortic valve successfully simulated the degradation of valve function over time, showing progressive narrowing of the valve orifice and increased peak fluid velocity in calcific aortic stenosis.
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