What question did this study set out to answer?

To review the regulatory cross-talk between Sirt1 and nuclear receptors in metabolic syndrome and inherited disorders of one-carbon metabolism.

August 11, 2020CellsOpen Access

Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism

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Design

Review

Authors

VKViola J. KosgeiMoi University DCDavid CoelhoInserm RGRosa‐Maria Guéant‐RodriguezInserm

Discussion

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Implication

Sirt1 reduction was associated with cardiometabolic disease but should not yet change practice; leaves open whether restoring it improves CV outcomes.

Key Points

To review the regulatory cross-talk between Sirt1 and nuclear receptors in metabolic syndrome and inherited disorders of one-carbon metabolism.
Synthesized molecular, preclinical animal model, and clinical trial evidence evaluating Sirt1 interactions with PGC1α and Foxo1 across different nutritional states.
Assessed rat models of maternal vitamin B12 and folate deficiency during gestation and lactation to identify mechanisms of fetal metabolic programming.
Sirt1 expression decreases in obesity, type 2 diabetes, cardiovascular disease, and nonalcoholic liver disease, while its overexpression attenuates diet-induced inflammation and macrophage infiltration.
Maternal folate and vitamin B12 deficiency triggers endoplasmic reticulum stress and ELAVL1/HuR mislocalization, downregulating Sirt1 via imbalanced PGC1α methylation and acetylation in fetal rat tissues.
Sirt1 agonists produce mixed efficacy in clinical trials for metabolic syndrome but demonstrate encouraging preclinical results for treating inherited vitamin B12 metabolic disorders.

Cite This Study

Kosgei et al. (2020) studied this question.

synapsesocial.com/papers/6a80272dfcb29c286731c369 https://doi.org/10.3390/cells9081882

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August 11, 2020CellsOpen Access

Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism

View Full Paper

Ask AI

Bookmark

Design

Review

Authors

VKViola J. KosgeiMoi University DCDavid CoelhoInserm RGRosa‐Maria Guéant‐RodriguezInserm

Discussion

Member takes

Implication

Sirt1 reduction was associated with cardiometabolic disease but should not yet change practice; leaves open whether restoring it improves CV outcomes.

Key Points

To review the regulatory cross-talk between Sirt1 and nuclear receptors in metabolic syndrome and inherited disorders of one-carbon metabolism.
Synthesized molecular, preclinical animal model, and clinical trial evidence evaluating Sirt1 interactions with PGC1α and Foxo1 across different nutritional states.
Assessed rat models of maternal vitamin B12 and folate deficiency during gestation and lactation to identify mechanisms of fetal metabolic programming.
Sirt1 expression decreases in obesity, type 2 diabetes, cardiovascular disease, and nonalcoholic liver disease, while its overexpression attenuates diet-induced inflammation and macrophage infiltration.
Maternal folate and vitamin B12 deficiency triggers endoplasmic reticulum stress and ELAVL1/HuR mislocalization, downregulating Sirt1 via imbalanced PGC1α methylation and acetylation in fetal rat tissues.
Sirt1 agonists produce mixed efficacy in clinical trials for metabolic syndrome but demonstrate encouraging preclinical results for treating inherited vitamin B12 metabolic disorders.

Cite This Study

Kosgei et al. (2020) studied this question.

synapsesocial.com/papers/6a80272dfcb29c286731c369 https://doi.org/10.3390/cells9081882

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