Two muscle biopsies were made in a case of chloroquine neuromyopathy in a 57-year-old woman with discoid lupus erythematosus. Histological study demonstrates widespread granulovacuolar degeneration and alterations of terminal innervation. Ultrastructural changes include formation of myelin figures and autophagic vacuoles. Of particular interest is the amount and mode of recovery from such alterations 2 months after cessation of the treatment.
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Gérard et al. (2008) studied this question.
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