Population
Four pluripotent cell lines
Comparison
Induction with activin-A and Bmp4 in defined… vs Comparison between hESC lines and hiPSC lines
Design
Preclinical
Follow-up
3-4 weeks
Authors
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hiPSC lines show inferior cardiomyocyte maturation vs hESCs; leaves open whether optimized protocols can enable cardiac regeneration.
Current methods for inducing cardiomyogenesis yield poorer terminal differentiation in hiPSCs compared to hESCs, suggesting a need for refined protocols for cardiac regeneration applications.
Šepac et al. (2012) studied this question.
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