Why the study?
Dedifferentiated liposarcomas rarely undergo metaplastic bone formation, prompting the report of a rare presentation with an osseous component.
This case report documents a rare occurrence of dedifferentiated liposarcoma with metaplastic bone formation in the upper extremity.
Complete resection and close follow-up remain standard for rare osseous DDL; leaves open molecular mechanisms of metaplastic bone formation.
Liposarcomas are the most common soft tissue sarcoma primarily originating in deep soft tissues and the retroperitoneum. Sarcoma classification includes atypical lipomatous tumor/well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL), myxoid liposarcoma, and pleomorphic liposarcoma. DDL is most prevalent in the retroperitoneum and often has two distinct components, a well-differentiated lipomatous component and a dedifferentiated nonlipomatous component that could be morphologically similar to malignant fibrous histiocytoma (MFH) or fibrosarcoma. DDLs can undergo heterologous differentiation into multiple cancer types including rhabdomyosarcoma, chondrosarcoma, melanoma, and leiomyosarcoma. Rarely, DDLs can undergo metaplastic bone formation. We report a peculiar case of a DDL with an osseous component.
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Ihionkhan et al. (2024) studied this question.
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