Why the study?
Does 1H-MRS provide reproducible measurements of myoglobin de- and reoxygenation in skeletal muscle of healthy controls and PAD patients?
Does 1H-MRS provide reproducible measurements of myoglobin de- and reoxygenation in skeletal muscle of healthy controls and PAD patients?
1H-MRS is a reproducible, noninvasive method to quantify skeletal muscle oxygenation and reperfusion, offering a potential tool to monitor therapies in peripheral arterial disease.
1H-MRS may enable noninvasive muscle oxygenation assessment in PAD; leaves open its role in therapy monitoring pending prospective validation.
1H-magnetic resonance spectroscopy ((1)H-MRS) of deoxymyoglobin (DMb) provides a means to noninvasively monitor the oxygenation state of human skeletal muscle in work and disease. As shown in this work, it also offers the opportunity to measure the absolute tissue content of DMb, the basic oxygen consumption of resting muscle, and the reperfusion characteristics after release of a pressure cuff. The methodology to determine these tissue properties simultaneously at two positions along the calf is presented. The obtained values are in agreement with invasive determinations. The reproducibility of the (1)H-MRS measurements is established for healthy controls and patients with peripheral arterial disease (PAD). A location dependence in axial direction, as well as differences between controls and patients are demonstrated for all parameters. The reoxygenation time in particular is expected to provide a means to quantitatively monitor therapies aimed at improving muscular perfusion in these patients.
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Kreis et al. (2001) studied this question.
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