August 15, 2026Journal of the American College of Cardiology323 citationsOpen Access
Coronary Artery Disease in Patients ≥80 Years of Age
Key Result
A systematic review of coronary artery disease in patients ≥80 years of age emphasizes the need for a patient-centered approach considering frailty, cognitive skills, and patient preferences.
Key Points
- To synthesize the current evidence, identify knowledge gaps, and propose future research directions regarding the pathophysiology, diagnosis, and management of coronary artery disease in individuals aged 80 years and older.
- Conducted a systematic review examining epidemiological data, clinical trial representation, diagnostic modalities, and therapeutic strategies for coronary artery disease in adults aged ≥80 years.
- Identifies that adults aged ≥80 years carry substantial coronary artery disease morbidity and mortality yet remain systematically underrepresented in cardiovascular clinical trials.
- Highlights that effective clinical management in this cohort requires a tailored, patient-centered approach accounting for frailty, functional capacity, cognitive status, and individual care preferences.
Study Design
Type
Systematic Review
PICO
P
Population
Systematic review focusing on the pathophysiology, epidemiology, diagnosis, and treatment of coronary artery disease in patients ≥80 years of age.
Abstract
Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients ≥80 years of age. Nonetheless, older patients have typically been under-represented in cardiovascular clinical trials. Understanding the pathophysiology, epidemiology, and optimal means of diagnosis and treatment of CAD in older adults is crucial to improving outcomes in this high-risk population. A patient-centered approach, taking into account health status, functional ability and frailty, cognitive skills, and patient preferences is essential when caring for older adults with CAD. The present systematic review focuses on the current knowledge base, gaps in understanding, and directions for future investigation pertaining to CAD in patients ≥80 years of age.