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Key Points α genes and CAR haplotypes independently impact hemolytic anemia severity; low G6PD-activity impacts anemia severity in CAR/CAR patients. BEN/BEN patients have a higher prevalence of the favorable BCL11A/rs1427407 T allele and a better response to HU than CAR/CAR patients.
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Bernaudin et al. (2018) studied this question.
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