Biochemistry of Interorganelle Transport

To understand the biochemical mechanisms fundamental to secretion, a number of model cell-free systems have emerged to study organelle structure and interorganelle transport. From these studies a surprising overlap is found in the components active at different stages of the exocytic pathway. In addition to the common requirement for all secretory organelles to be tethered to a microtubule-based cytoskeleton, at least four factors are now recognized to be essential for transport of protein between more than one stage of the pathway