Cellularized, needle-deployed intracortical arrays for brain electrophysiology

Bioelectronic medicine enables direct interfacing with native cell populations but remains limited by poor long-term integration and minimal interaction with non-electroactive cells. In contrast, regenerative medicine promotes tissue integration yet lacks bidirectional functionality. Here, we present a hybrid implantation methodology combining a tissue engineered cellularized hydrogel with a neural recording array for simultaneous delivery into the brain via needle placement. This approach enables co-localized transplantation of cells and electronics while minimizing surgical footprint. Post-implantation electrophysiological recordings show functional integration with surrounding neural tissue, demonstrating the feasibility of this platform for coupled bioelectronic sensing and regenerative capabilities.