The association of glycemic control with patient survival and technique survival in incident diabetic peritoneal dialysis patients (Submission ID 967fc136-619c-44ff-ad33-fad02d67a928)

This study investigated the prognosis in incident peritoneal dialysis (PD) patients with diabetes by glycemic control status. From medical records, 259 newly diagnosed end–stage kidney disease patients with diabetes undergoing PD from 2007 to 2016 were identified to estimate risks of mortality and technique failure associated with hemoglobin A1c (HbA1c) and fasting blood glucose levels with follow-up through December 31, 2018. Compared to patients with time–averaged A1c values ≥ 9%, patients with A1c of 6–6.9% and 7–7.9% had adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.39 (0.20–0.78) and 0.47 (0.24–0.91), respectively, for mortality, and 0.55 (0.33–0.92) and 0.53 (0.31–0.90), respectively, for technical failure. The adjusted HR and 95% CI for technique failure was 0.50 (0.21–0.97) for patients with baseline fasting blood glucose levels of 70–< 150 mg/dL, compared to those with levels ≥ 300 mg/dL. The adjusted HR and 95% CI for mortality was 0.53 (0.29–0.99) for patients with time–averaged fasting blood glucose levels of 70–< 150 mg/dL, compared to those with levels of 200–300 mg/dL. However, neither baseline nor time-averaged fasting blood glucose levels were significantly associated with risks of mortality or technique failure when 150–<200 mg/dL was used as the reference group. Diabetic PD patients with time–averaged HbA1c levels of 6–7.9% was at a reduced mortality risk. The time–averaged HbA1c levels of 6–7.9% was associated with a reduced risk of technique failure in this population. Not applicable.