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A cavity closed on one side is evident in the solid-state structure of α-cycloaltrin (see picture on the right). This novel non-glucose cyclooligosaccharide is constructed of alternating 1C4 and 4C1 chair conformations of the altropyranoid rings. In aqueous solution an equilibrium between the 1C4 and 0S2 (skew) forms is established. α-Cycloaltrin is prepared from α-Cyclodextrin in a straightforward four-step protocol in which the 2,3-anhydro-α-cyclomannin is the key intermediate.
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Nogami et al. (1997) studied this question.
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