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January 17, 2017The Prostate

Prognostic Role of Preoperative Serum Lipid Levels in Patients Undergoing Radical Prostatectomy for Clinically Localized Prostate Cancer

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Why the study?

Do preoperative serum lipid levels predict recurrence-free survival in men undergoing radical prostatectomy for localized prostate cancer?

Population

371 men with clinically localized prostate cancer undergoing radical prostatectomy, median age 63 years.

Comparison

Preoperative serum lipid levels and statin use vs High vs low LDL cholesterol levels

Design

Cohort

Follow-up

median 28 months (range 1-64)

Authors

MWMarian S. WettsteinThe University of MelbourneKSKarim SabaHirslanden Klinik AarauMUMartin UmbehrJohns Hopkins University

Discussion

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Member takes

Implication

Does not yet inform preoperative lipid management in prostatectomy patients; leaves open whether LDL predicts recurrence in prospective studies.

Structured PICO

Do preoperative serum lipid levels predict recurrence-free survival in men undergoing radical prostatectomy for localized prostate cancer?

P
Population
371 men with clinically localized prostate cancer undergoing radical prostatectomy, median age 63 years.
I
Intervention
Preoperative serum lipid levels (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides) and statin use
C
Comparator
High vs low LDL cholesterol levels (e.g., 3 mM cut-point)
O
Outcome
Recurrence-free survival (RFS), defined as rising and verified PSA levels >0.1 ng/mlsurrogate

Low preoperative LDL cholesterol levels are an independent predictor of prostate cancer recurrence after radical prostatectomy.

Cite This Study

Wettstein et al. (2017) studied this question.

synapsesocial.com/papers/6a80571c1c96fcc8ad701fa0https://doi.org/10.1002/pros.23296
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge1972 · 32,641 citations
  2. 2Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)2001 · 26,208 citations
  3. 3Long‐term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate‐specific antigen era2009 · 94 citations
  4. 4Statin Use and Risk of Prostate Cancer Recurrence in Men Treated With Radiation Therapy2010 · 153 citations
  5. 5Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells1978 · 279 citations