To the editor: Cold agglutinin disease (CAD) is characterized by immunoglobulin M (IgM)–mediated hemagglutination and robust complement activation leading to intravascular hemolysis and hemolysis-related symptoms including anemia, fatigue, dyspnea, hemoglobinuria, and acrocyanosis.[1][1][⇓][2
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Röth et al. (2009) studied this question.
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