Answers are grounded in this paper and cite their sources.
In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor formation in humans and data was presented which describe a molecular mechanism for these phenotypes.
No takes yet. Share an insight, caveat, or question.
Bond et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: