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November 1, 2004EP Europace

A new treatment for atrial fibrillation based on spectral analysis to guide the catheter RF-ablation

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Why the study?

Does radiofrequency ablation targeting AF nests guided by spectral analysis prevent AF relapse in patients with idiopathic drug-refractory paroxysmal or persistent AF?

Population

40 patients, including 6 controls and 34 with idiopathic drug-refractory paroxysmal or persistent atrial…

Design

Cohort

Follow-up

9.9 +/- 5 months

Authors

JPJuán Carlos Pachón-MUniversidade de São PauloJPJuán Carlos Pachón-MUniversidade de São PauloTLTasso J. LoboHospital do Coração

Discussion

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Implication

May reduce relapse in drug-refractory paroxysmal AF; leaves open confirmation in randomized trials.

Structured PICO

Does radiofrequency ablation targeting AF nests guided by spectral analysis prevent AF relapse in patients with idiopathic drug-refractory paroxysmal or persistent AF?

P
Population
40 patients, including 6 controls and 34 with idiopathic drug-refractory paroxysmal or persistent atrial fibrillation
I
Intervention
Radiofrequency ablation (30-40 J/60-70 degrees C) targeting AF nests (sites outside the pulmonary veins presenting right-FFT-shift identified by spectral analysis)
O
Outcome
Elimination of paroxysmal AF / AF relapse at 9.9 +/- 5 months follow-uphard clinical

Spectral analysis-guided radiofrequency ablation targeting AF nests outside the pulmonary veins is a highly effective novel strategy for eliminating paroxysmal AF while potentially avoiding pulmonary vein stenosis.

Cite This Study

Pachón-M et al. (2004) studied this question.

synapsesocial.com/papers/6a805cee04b22a52ede47ed8https://doi.org/10.1016/j.eupc.2004.08.005

Topics

Atrial fibrillationPersistent AF managementAF ablation outcomesAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Radiofrequency ablation of the pulmonary veins: Can it stop atrial fibrillation at its source?2001 · 5 citations
  2. 2Treatment of Paroxysmal Atrial Fibrillation by Pulmonary Vein Isolation2003 · 28 citations
  3. 3Segmental Ostial Ablation to Isolate the Pulmonary Veins During Atrial Fibrillation2002 · 245 citations
  4. 4Initiation of Atrial Fibrillation by Ectopic Beats Originating From the Pulmonary Veins1999 · 1,468 citations
  5. 5Efficacy and Safety of Targeted Focal Ablation Versus PV Isolation Assisted by Magnetic Electroanatomic Mapping2003 · 108 citations