September 1, 1998Annals of the New York Academy of Sciences

Sites of Regulatory Interaction between Calcium ATPases and Phospholambana

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Structured PICO

Population

In vitro molecular model studying Phospholamban (PLN) and cardiac sarcoplasmic reticulum Ca2+ ATPase (SERCA2a)

Intervention

Site-directed mutagenesis, chimera formation, and alanine-scanning mutagenesis

Outcome

Identification of interacting residues and sites of regulatory interaction between PLN and SERCA2asurrogate

This basic science study maps the regulatory interaction sites between phospholamban and SERCA2a, demonstrating that the inhibitory form of phospholamban is a monomer.

Discussion

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Implication

Maps PLN-SERCA2a sites in animals; leaves open translation to human HF therapies.

Cite This Study

MacLennan et al. (1998) studied this question.

synapsesocial.com/papers/6a80619b1024bacc9692a4aa https://doi.org/10.1111/j.1749-6632.1998.tb08254.x

View Full Paper

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Sites of Regulatory Interaction between Calcium ATPases and Phospholambana

Structured PICO

Discussion

Implication

Cite This Study

Sites of Regulatory Interaction between Calcium ATPases and Phospholambana

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider