Dialysate sodium and sodium gradient in maintenance hemodialysis: a neglected sodium restriction approach?
Why the study?
Is a higher sodium gradient during hemodialysis associated with increased interdialytic weight gain, blood pressure, and thirst in stable hemodialysis patients?
Population
1084 clinically stable patients on maintenance hemodialysis
Comparison
Higher sodium gradient vs Lower sodium gradient
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Sodium gradient associated with higher IDWG in HD; hypothesis-generating for individualized dialysate sodium to curb thirst and weight gain.
Structured PICO
Is a higher sodium gradient during hemodialysis associated with increased interdialytic weight gain, blood pressure, and thirst in stable hemodialysis patients?
P
Population
1084 clinically stable patients on maintenance hemodialysis
I
Intervention
Higher sodium gradient (dialysate sodium minus pre-dialysis plasma sodium)
C
Comparator
Lower sodium gradient (evaluated as a continuous variable)
O
Outcome
Interdialytic weight gain (IDWG)surrogate
A higher sodium gradient during hemodialysis is independently associated with increased interdialytic weight gain and post-dialysis thirst, highlighting the potential importance of individualizing dialysate sodium prescriptions.
Cite This Study
Mendoza et al. (2011) studied this question.