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August 12, 2009Nephrology Dialysis TransplantationOpen Access

NT-proBNP, fluid volume overload and dialysis modality are independent predictors of mortality in ESRD patients

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Why the study?

Do NT-proBNP levels and fluid volume overload independently predict mortality in ESRD patients across different dialysis modalities?

Population

753 prevalent adult patients with end-stage renal disease on continuous ambulatory peritoneal dialysis…

Design

Cohort

Follow-up

16 months

Authors

RPRicardo PaniaguaSan Diego State UniversityMVMaría de Jesús VenturaMexican Social Security InstituteHHHéctor Hinojosa-HerediaHospital General de México

Discussion

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Implication

May inform mortality risk stratification in ESRD; extends observational data but leaves open whether targeting these markers improves outcomes.

Structured PICO

Do NT-proBNP levels and fluid volume overload independently predict mortality in ESRD patients across different dialysis modalities?

P
Population
753 prevalent adult patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD), automated peritoneal dialysis (APD), and haemodialysis (HD)
I
Intervention
Measurement of NT-proBNP levels and extracellular fluid volume/total body water ratio (ECFv/TBW)
O
Outcome
All-cause and cardiovascular mortalityhard clinical

NT-proBNP and fluid volume overload are independent predictors of all-cause and cardiovascular mortality in ESRD patients, regardless of the dialysis modality used.

Cite This Study

Paniagua et al. (2009) studied this question.

synapsesocial.com/papers/6a8064952cf87dafd7c88d37https://doi.org/10.1093/ndt/gfp395
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Also Consider

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  1. 1Changes in Brain Natriuretic Peptide and Atrial Natriuretic Peptide Plasma Concentrations During Hemodialysis in Patients with Chronic Renal Failure1994 · 29 citations
  2. 2Endothelin and Atrial Natriuretic Peptide in Non-Insulin-Dependent Diabetic Versus Nondiabetic Patients on Chronic Hemodialysis1994 · 9 citations
  3. 3Cardiovascular risk in end-stage renal disease: vascular aspects2000 · 57 citations
  4. 4Heart Failure and Nephropathy2005 · 65 citations
  5. 5Markers of Inflammation and Cardiovascular Disease2003 · 6,428 citations