What question did this study set out to answer?

To determine whether CRLF2 gene rearrangements and IKZF1 deletions provide a biological basis for health disparities and worse prognosis in Hispanic/Latino pediatric B-ALL.

February 2, 2021LeukemiaOpen Access

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity

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To determine whether CRLF2 gene rearrangements and IKZF1 deletions provide a biological basis for health disparities and worse prognosis in Hispanic/Latino pediatric B-ALL.
Analyzed clinical and molecular data from 239 pediatric B-ALL patients (164 Hispanic/Latino, 75 non-Hispanic/Latino) treated at Children's Hospital Los Angeles between March 2016 and July 2019.
Evaluated the incidence of IGH-CRLF2 translocations, P2RY8-CRLF2 fusions, IKZF1 deletions, and their co-occurrence across racial/ethnic groups and age strata.
Hispanic/Latino children had a significantly higher incidence of IGH-CRLF2 translocations (12% [19/164] vs. 2.7% [2/75], p = 0.026) and IKZF1 deletions (29% [48/164] vs. 15% [11/75], p = 0.016) than non-Hispanic/Latino children.
Concomitant IKZF1 deletion and IGH-CRLF2 translocation occurred in 11% (18/164) of Hispanic/Latino patients versus 0% (0/75) of non-Hispanic/Latino patients (p = 0.001).
In children ≥10 years old, IKZF1 deletions were markedly higher in Hispanic/Latino patients (59% [35/59] vs. 21% [5/24], OR 5.4, p = 0.002), as were IGH-CRLF2 translocations (31% [18/59] vs. 0% [0/24], p = 0.001).

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Implication

Observational study reveals increased IKZF1 deletions and IGH-CRLF2 translocations in Hispanic pediatric B-ALL, suggesting a biological basis for survival disparities.

Cite This Study

Raca et al. (2021) studied this question.

synapsesocial.com/papers/6a80725903a7c7d587cae529 https://doi.org/10.1038/s41375-021-01133-4

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Implication

Observational study reveals increased IKZF1 deletions and IGH-CRLF2 translocations in Hispanic pediatric B-ALL, suggesting a biological basis for survival disparities.

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity

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Discussion

Implication

Cite This Study

Increased Incidence of IKZF1 deletions and IGH-CRLF2 translocations in B-ALL of Hispanic/Latino children—a novel health disparity

Key Points

Discussion

Implication

Cite This Study

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