Mouse models with targeted mutations are valuable tools for understanding the complex genetic control of cardiac development and human congenital cardiovascular anomalies.
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Mouse models advance genetic insights into congenital heart defects; leaves open clinical translation pending human validation studies.
Understanding the genetic control of cardiac development has been greatly assisted by the newly acquired ability to generate targeted mutations in the mouse. A number of mutations in genes that directly or indirectly affect cardiac development have now been reported, and the phenotypes of these mutations have suggested that cardiac development is under complex genetic control. Further analysis of the mouse model system should help elucidate the etiology of human congenital cardiovascular anomalies.
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Janet Rossant (1996) studied this question.
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