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June 6, 2014Circulation Heart FailureOpen Access

A Bioengineered Hydrogel System Enables Targeted and Sustained Intramyocardial Delivery of Neuregulin, Activating the Cardiomyocyte Cell Cycle and Enhancing Ventricular Function in a Murine Model of Ischemic Cardiomyopathy

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Why the study?

Does intramyocardial delivery of Neuregulin-1β encapsulated in hydrogel improve ventricular function and cardiomyocyte proliferation in a murine model of ischemic cardiomyopathy?

Population

2-month-old mice with left anterior descending coronary artery ligation; Sprague-Dawley rats used for in…

Comparison

Neuregulin-1β encapsulated in hydrogel delivered… vs PBS, Neuregulin-1β alone, or hydrogel alone.

Design

Preclinical, randomized

Follow-up

2 weeks

Authors

JCJeffrey Е. CohenMedStar Washington Hospital CenterBPBrendan P. PurcellUniversity of PennsylvaniaJMJohn W. MacArthurStanford University

Discussion

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Implication

Supports NRG-1β hydrogel exploration in murine ischemic cardiomyopathy; leaves open clinical translation.

Structured PICO

Does intramyocardial delivery of Neuregulin-1β encapsulated in hydrogel improve ventricular function and cardiomyocyte proliferation in a murine model of ischemic cardiomyopathy?

P
Population
2-month-old mice (n=60) with left anterior descending coronary artery ligation (ischemic cardiomyopathy model); Sprague-Dawley rats used for in vitro cardiomyocyte isolation.
I
Intervention
Neuregulin-1β encapsulated in hydrogel (NRG-HG) delivered directly to the myocardium.
C
Comparator
PBS, Neuregulin-1β alone, or hydrogel alone.
O
Outcome
Cardiomyocyte proliferation (EdU, phosphorylated histone H3, Ki67 positivity), apoptosis (caspase-3 activity), and left ventricular function (LVEF, LV area, borderzone thickness) at 2 weeks.surrogate

Targeted intramyocardial delivery of Neuregulin-1β via hydrogel enhances cardiomyocyte proliferation and improves left ventricular function in a murine model of ischemic cardiomyopathy, avoiding off-target exposure.

Cite This Study

Cohen et al. (2014) studied this question.

synapsesocial.com/papers/6a807a8d03a7c7d587cae86bhttps://doi.org/10.1161/circheartfailure.113.001273

Topics

Cardiomyopathy
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