Key result
Higher GGT linked to ~66% greater CV mortality in both men and women.
Why the study?
Few studies with sufficient sample size and follow-up have investigated the association of gamma-glutamyltransferase (GGT) with cardiovascular disease mortality.
Does high gamma-glutamyltransferase (GGT) predict cardiovascular disease mortality in adults?
Population
163,944 Austrian adults
Comparison
High versus low gamma-glutamyltransferase levels
Design
Prospective cohort study with Cox proportional hazards models adjusted for established risk factors
Follow-up
Up to 17 years
Authors
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GGT was associated with CVD mortality independent of risk factors; leaves open added predictive value or clinical measurement.
Cohort (n=163,944)
Does high gamma-glutamyltransferase (GGT) predict cardiovascular disease mortality in adults?
Hazard Ratio: 1.66 (95% CI 1.4–1.98)
p-value: p=<0.001
Elevated gamma-glutamyltransferase (GGT) is an independent predictor of cardiovascular mortality in both men and women, with a stronger association in younger individuals.
Ruttmann et al. (2005) conducted a cohort in Cardiovascular disease (n=163,944). Gamma-glutamyltransferase (GGT) was evaluated on Total mortality from cardiovascular disease (HR 1.66, 95% CI 1.40-1.98, p=<0.001). Higher gamma-glutamyltransferase levels were significantly associated with increased cardiovascular mortality in both men (HR 1.66; 95% CI 1.40-1.98) and women (HR 1.64; 95% CI 1.36-1.97).
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