Key result
A 67-year-old male with acute myeloid leukemia presented atypically with simultaneous acute pulmonary embolism and acute myocardial infarction, ultimately succumbing to presumed intracranial bleeding.
Why the study?
Thrombotic complications in acute myeloid leukemia are uncommon due to coagulation dysfunction and thrombocytopenia.
Case Report (n=1)
Simultaneous acute pulmonary embolism and acute myocardial infarction can be a rare initial presentation of acute myeloid leukemia, presenting severe management dilemmas regarding antithrombotic therapy and bleeding risk.
May warrant considering occult AML in unexplained PE plus atypical MI; leaves open whether dual thrombosis requires hematologic screening.
Thrombotic complications in acute myeloid leukemia (AML) are uncommon due to coagulation dysfunction and thrombocytopenia. We report a unique case of AML presenting as concomitant pulmonary embolism and atypical acute myocardial infarction. A 67-year-old male experienced persistent bilateral chest pain. Despite an unremarkable electrocardiogram, elevated D-dimer and mildly increased troponin T levels prompted further investigation, leading to the diagnosis of simultaneous pulmonary embolism and acute myocardial infarction. The patient underwent percutaneous coronary intervention and received triple antithrombotic therapy. However, antithrombotic therapy was discontinued following a sharp decline in hemoglobin and platelet counts, and the patient subsequently developed persistent fever. AML was diagnosed via bone marrow biopsy. Chemotherapy was not initiated due to the patient's deteriorating condition, and he ultimately succumbed to presumed intracranial bleeding.
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Zheng et al. (2023) conducted a case report in Acute myeloid leukemia presenting as acute pulmonary embolism and acute myocardial infarction (n=1). Percutaneous coronary intervention and antithrombotic therapy was evaluated on Clinical outcome. A 67-year-old male with acute myeloid leukemia presented atypically with simultaneous acute pulmonary embolism and acute myocardial infarction, ultimately succumbing to presumed intracranial bleeding.
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