Key result
Advancing age was significantly correlated with echocardiographic parameters of right ventricular diastolic dysfunction, notably a decrease in E wave velocity that was more pronounced in women (r = -0.473, p < 0.001).
Why the study?
Right ventricle elasticity tends to decrease with aging and may alter its diastolic function, prompting evaluation of the correlation between echocardiographic RV diastolic changes and advancing age in individuals with normal biventricular systolic function.
Does advancing age correlate with echocardiographic changes in RV diastolic function in individuals with normal biventricular systolic function?
Cohort (n=110)
No
Does advancing age correlate with echocardiographic changes in RV diastolic function in individuals with normal biventricular systolic function?
Effect estimate: r = -0.473
p-value: p=<0.001
Echocardiographic parameters of right ventricular diastolic function, such as E wave velocity and E/A ratio, decrease significantly with advancing age, with changes being more pronounced in women.
May inform age- and sex-specific RV diastolic reference values; leaves open prognostic relevance in preserved systolic function.
Introduction: Right ventricle (RV) elasticity tends to decrease with aging and may alter its diastolic function.Objective: To evaluate the correlation between echocardiographic changes in RV diastolic function and advancing age in individuals with normal biventricular systolic function.Methods: This retrospective observational cohort study included 110 patients: 66 (60%) women (62 [SD, 13.7] years) and 44 (40%) men (60.6 [SD, 10.8] years).The transthoracic echocardiography data included: spectral Doppler of tricuspid inflow E wave, A wave, E/A ratio, and E wave deceleration time; tissue Doppler of lateral tricuspid annulus e' wave, a' wave, and E/e' ratio.Correlations were calculated using Pearson's and Spearman's correlation coefficients.Results: Only 35.2% of the sample had RV diastolic dysfunction.Of the evaluated echocardiographic variables, the E wave was negatively correlated with age in both women (r 0.473; p < 0.001) and men (r -0.37, p = 0.015).The E/A ratio was negatively correlated with age only in women (r -0.32; p = 0.001), and E wave deceleration time was positively correlated with age only in women (r 0.31; p = 0.014).The other variables were not significantly correlated with age in men or women.Conclusions: We found a significant correlation between age and echocardiographic parameters for RV diastolic dysfunction, which was more evident in women.
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Moura et al. (2023) conducted a cohort in Normal biventricular systolic function (n=110). Advancing age was evaluated on Correlation between E wave velocity and age in women (r = -0.473, p=<0.001). Advancing age was significantly correlated with echocardiographic parameters of right ventricular diastolic dysfunction, notably a decrease in E wave velocity that was more pronounced in women (r = -0.473, p < 0.001).
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