Why the study?
Little progress has been made in diagnosing or preventing perioperative AKI, partly due to late detection by conventional criteria based on functional biomarkers, serum creatinine, and urine output.
Do damage biomarkers and timely perioperative management improve the early detection and prevention of perioperative acute kidney injury compared to conventional functional biomarkers?
Design
Review
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May support earlier perioperative AKI detection; leaves open whether outcomes improve in prospective trials.
Do damage biomarkers and timely perioperative management improve the early detection and prevention of perioperative acute kidney injury compared to conventional functional biomarkers?
Damage biomarkers enable earlier detection of perioperative AKI than conventional criteria, allowing for timely preventive interventions such as optimizing volume status and perfusion.
Saadat-Gilani et al. (2021) studied this question.
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