Microsomal Prostaglandin E 2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction
Why the study?
Does mPGES-1 deletion worsen left ventricular remodeling and function after acute myocardial infarction in mice?
Population
Ptges(+/+) and Ptges(-/-) mice subjected to acute myocardial infarction
Comparison
Deletion of mPGES-1 (Ptges(-/-) genotype) vs Wild-type (Ptges(+/+)) mice
Design
Preclinical
Follow-up
28 days
Authors
Discussion
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Member takes
Implication
mPGES-1 deletion worsens post-MI remodeling in mice; leaves open whether mPGES-1 inhibitors impair human LV recovery after infarction.
Structured PICO
Does mPGES-1 deletion worsen left ventricular remodeling and function after acute myocardial infarction in mice?
P
Population
Ptges(+/+) and Ptges(-/-) mice subjected to acute myocardial infarction
I
Intervention
Deletion of mPGES-1 (Ptges(-/-) genotype)
C
Comparator
Wild-type (Ptges(+/+)) mice
O
Outcome
Left ventricular remodeling and function (LV dilation, systolic and diastolic function, LV end-diastolic pressure) at 28 days post-MIsurrogate
Deletion of mPGES-1 leads to eccentric cardiac myocyte hypertrophy, LV dilation, and impaired LV contractile function after acute MI in mice, suggesting a protective role for mPGES-1-derived PGE2.
Cite This Study
Degousée et al. (2008) studied this question.