What question did this study set out to answer?

To investigate the expression and pathogenic role of cysteine cathepsins and their endogenous inhibitor, cystatin C, during the progression of cerebral aneurysms.

July 18, 2008StrokeOpen Access

Cathepsin B, K, and S Are Expressed in Cerebral Aneurysms and Promote the Progression of Cerebral Aneurysms

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Authors

TATomohiro AokiJikei University School of Medicine HKHiroharu KataokaNational Cerebral and Cardiovascular Center RIRyota IshibashiRitsumeikan University

Discussion

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Implication

Preclinical study demonstrates that cysteine cathepsins B, K, and S drive arterial wall degradation in cerebral aneurysms, suggesting cathepsin inhibition may prevent disease progression.

Key Points

To investigate the expression and pathogenic role of cysteine cathepsins and their endogenous inhibitor, cystatin C, during the progression of cerebral aneurysms.
Induced cerebral aneurysms in Sprague-Dawley rats treated with or without the cysteine cathepsin inhibitor NC-2300.
Quantified the expression of cathepsins B, K, S, and cystatin C using quantitative RT-PCR and immunohistochemistry in both rat models and human cerebral aneurysm tissues.
Measured enzymatic activities of cysteine cathepsins and collagenase types I and IV alongside arterial wall elastin content.
Expression of cathepsins B, K, and S was markedly upregulated in late-stage aneurysms, while expression of the endogenous inhibitor cystatin C decreased.
Inhibition with NC-2300 reduced the incidence of advanced cerebral aneurysms, suppressed cysteine cathepsin and collagenase I and IV activity, and preserved arterial elastin content.
Human cerebral aneurysm tissues exhibited an expression pattern consistent with animal models, confirming elevated cysteine cathepsins and depleted cystatin C.

Cite This Study

Aoki et al. (2008) studied this question.

synapsesocial.com/papers/6a808351ea50fa4f079294e9 https://doi.org/10.1161/strokeaha.107.513648

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Implication

Preclinical study demonstrates that cysteine cathepsins B, K, and S drive arterial wall degradation in cerebral aneurysms, suggesting cathepsin inhibition may prevent disease progression.

Cathepsin B, K, and S Are Expressed in Cerebral Aneurysms and Promote the Progression of Cerebral Aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

Cathepsin B, K, and S Are Expressed in Cerebral Aneurysms and Promote the Progression of Cerebral Aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

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