Key result
IVGG-resistant Kawasaki disease is linked to a ~44% coronary aneurysm rate and elevated VEGF.
Why the study?
Increased microvascular permeability is an initial step in Kawasaki disease, but the prognostic impact of vascular leakage remains unclear.
Does vascular leakage impact prognosis and response to IVGG in patients with acute Kawasaki disease?
Observational (n=103)
Does vascular leakage impact prognosis and response to IVGG in patients with acute Kawasaki disease?
Absolute Event Rate: 44.4% vs 0%
Vascular leakage, indicated by elevated VEGF, hypoalbuminemia, and body weight gain, is associated with IVGG resistance and the development of coronary aneurysms in acute Kawasaki disease.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice based on post-IVIG weight gain; leaves open vascular leakage as a trial target in resistant Kawasaki disease.
Terai et al. (2003) conducted an observational in Acute Kawasaki disease (n=103). IVGG resistance vs. IVGG responsiveness was evaluated on Coronary aneurysms. IVGG-resistant Kawasaki disease patients exhibited higher VEGF levels, severe hypoalbuminemia, and a higher incidence of coronary aneurysms (44.4% vs 0%) compared to IVGG-responsive patients.
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