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Racemization suppression by the addition of ethyl 2-hydroximino-2-cyanoacetate (IIIa) or 2-hydroximino-2-cyanoacetamide (IIIb), during coupling stages in peptide synthesis, was studied. The effectiveness of IIIa was compared with these of known additives by the help of Bodanszky’s test, which is a simple and accurate method for racemization detection.
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Masumi Itoh (1973) studied this question.
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