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September 11, 2024Thrombosis ResearchOpen Access

Rate and predictors of thromboprophylaxis in internal medicine wards: Results from the AURELIO study

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Why the study?

Randomized trials show anticoagulant prophylaxis effectively prevents VTE in hospitalized medical patients with high risk, but prospective real-world data on prophylactic anticoagulant use were lacking.

Population

2371 unselected acutely ill patients hospitalized in medical wards

Comparison

Pharmacological thromboprophylaxis administration vs no prophylaxis

Design

Multicenter prospective observational study

Follow-up

Median length of hospitalization was 13 ± 12 days

Authors

AMArianna MagnaEMEnrico MaggioGVGianpaolo Vidili

Discussion

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Member takes

Overview

Highlights persistent underuse of VTE prophylaxis in medical wards; leaves open implementation strategies targeting identified high-risk predictors.

Structured PICO

P
Population
2,371 unselected acutely ill patients hospitalized in medical wards (1,233 males [52%], 1,138 females [48%]; mean age 72 ± 16 years).
I
Intervention
Prophylactic parenteral anticoagulants (subcutaneous low molecular weight heparin or fondaparinux once daily) at admission
C
Comparator
No prophylactic parenteral anticoagulants
O
Outcome
Rate of deep vein thrombosis (DVT) assessed by compression ultrasound (CUS) at admission and discharge, and rate of pharmacological thromboprophylaxis administrationhard clinical

In real-world internal medicine wards, only 18.6% of acutely ill patients receive pharmacological thromboprophylaxis, with administration driven by factors such as reduced mobility, active cancer, and previous VTE.

Cite This Study

Magna et al. (2024) studied this question.

synapsesocial.com/papers/6a80846003a7c7d587caecb0https://doi.org/10.1016/j.thromres.2024.109148
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Also Consider

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  4. 4American Society of Hematology 2018 guidelines for management of venous thromboembolism: optimal management of anticoagulation therapy2018 · 517 citations
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