Key result
Open surgery significantly increased the risk of postoperative acute kidney injury compared to laparoscopic surgery (OR 2.26) among patients with colorectal cancer, alongside other identified risk factors such as chronic kidney disease and ASA score ≥ 3.
Why the study?
To thoroughly examine the risk factors that may predispose patients with colorectal cancer to postoperative acute kidney injury.
Meta-Analysis (n=167,904)
Odds Ratio: 2.26 (95% CI 1.78–2.88)
p-value: p=<0.0001
Multiple patient-related and surgery-related risk factors, including CKD, ASA score ≥ 3, and open surgery, significantly increase the risk of postoperative AKI in colorectal cancer patients.
Purpose To thoroughly examine the risk factors that may predispose patients with colorectal cancer to postoperative acute kidney injury (AKI). Methods To find relevant studies (from the beginning up to May 2024), two researchers searched PubMed, Web of Science, the Cochrane Library, and Embase databases. Two researchers evaluated the quality of the literature using the Newcastle–Ottawa Scale (NOS) and extracted data individually. Data analysis was performed using the Review Manager 5.4. Results Our meta-analysis included 23 studies, encompassing a total of 167,904 patients. The identified risk factors for postoperative AKI in colorectal cancer patients were male sex, older age, body mass index (BMI) ≥ 25 kg/m 2 , hypertension, diabetes mellitus (DM), chronic kidney disease (CKD), hypoalbuminemia, emergency surgery, open surgery, prolonged operation time, American Society of Anesthesiologists (ASA) score ≥ 3, and intraoperative transfusion. In contrast, anemia and elevated creatinine levels did not emerge as significant risk factors for AKI in this population. Conclusion To mitigate the incidence of postoperative AKI among these patients, healthcare professionals must proactively identify these risk factors and implement appropriate preventive measures.
No takes yet. Share an insight, caveat, or question.
Huang et al. (2025) conducted a meta-analysis in Colorectal cancer (n=167,904). Open surgery vs. Laparoscopic surgery was evaluated on Postoperative acute kidney injury (AKI) (OR 2.26, 95% CI 1.78-2.88, p=<0.0001). Open surgery significantly increased the risk of postoperative acute kidney injury compared to laparoscopic surgery (OR 2.26) among patients with colorectal cancer, alongside other identified risk factors such as chronic kidney disease and ASA score ≥ 3.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: