Association between QTc prolongation and mortality in patients with suspected poisoning in the emergency department: a transnational propensity score matched cohort study
Why the study?
Does a prolonged QTc interval increase the risk of mortality or cardiac arrest in adult patients presenting to the emergency department with suspected poisoning?
Population
3,869 adult first-time contacts with suspected poisoning to the emergency department who had an ECG recorded…
Comparison
Prolonged QTc interval vs QTc interval of <440 ms
Design
Cohort
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
May identify higher-risk ED poisoning patients; leaves open whether QTc refines triage or outcomes.
Structured PICO
Does a prolonged QTc interval increase the risk of mortality or cardiac arrest in adult patients presenting to the emergency department with suspected poisoning?
P
Population
3,869 adult first-time contacts with suspected poisoning to the emergency department who had an ECG recorded within 4 hours after arrival
I
Intervention
Prolonged QTc interval (≥450 ms men, ≥460 ms women)
C
Comparator
QTc interval of <440 ms
O
Outcome
Composite of all-cause mortality or cardiac arrest within 30 days after contactcomposite
In emergency department patients with suspected poisoning, a prolonged QTc interval on arrival is associated with a significantly increased risk of 30-day mortality or cardiac arrest.
Cite This Study
Hansen et al. (2018) studied this question.