June 27, 2012European Heart JournalOpen Access

High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate

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Why the study?

Are elevated hsTnT and NT-pro-BNP associated with incident cardiovascular events independently of renal function (eGFR and albuminuria) in a population-based cohort?

Population

8,121 subjects from the population-based PREVEND study cohort, mainly consisting of individuals with mildly…

Comparison

Elevated high-sensitive troponin T and… vs Non-elevated levels of hsTnT and NT-pro-BNP

Design

Cohort

Authors

LSLieneke SchevenUniversity Medical Center Groningen PJPaul E. de JongAga Khan University HHHans L. HillegeHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

hsTnT and NT-proBNP predict CV events independently of renal markers; supports their prognostic role in mild CKD but leaves open clinical integration.

Structured PICO

Are elevated hsTnT and NT-pro-BNP associated with incident cardiovascular events independently of renal function (eGFR and albuminuria) in a population-based cohort?

Population

8,121 subjects from the population-based PREVEND study cohort, mainly consisting of individuals with mildly impaired renal function (chronic kidney disease stages 1-3).

Intervention

Elevated high-sensitive troponin T (hsTnT >0.01 µg/L) and N-terminal pro-B-type natriuretic peptide (NT-pro-BNP >125 ng/L)

Comparator

Non-elevated levels of hsTnT (≤0.01 µg/L) and NT-pro-BNP (≤125 ng/L)

Outcome

Incident cardiovascular eventshard clinical

Elevated hsTnT and NT-pro-BNP are independent prognostic markers for cardiovascular events in patients with mildly impaired renal function and should not be dismissed as merely reflecting decreased renal clearance.

Limitations

Only a few subjects with markedly reduced renal function were included, meaning results are mainly valid for a population with mildly impaired renal function.

Cite This Study

Scheven et al. (2012) studied this question.

synapsesocial.com/papers/6a8096541c96fcc8ad70354a https://doi.org/10.1093/eurheartj/ehs163

Topics

Women and heart disease

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Implication

hsTnT and NT-proBNP predict CV events independently of renal markers; supports their prognostic role in mild CKD but leaves open clinical integration.

High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider